Cyclo(-D-Leu-D-Pro)是一种来源于Pseudonocardia endophytica VUK-10的环状二肽，具有抗真菌活性。
Cas No.:274680-11-4
Sample solution is provided at 25 µL, 10mM.
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Cyclo(-D-Leu-D-Pro) is a cyclic dipeptide from Pseudonocardia endophytica VUK-10, with antifungal activities [1]. Cyclo(-D-Leu-D-Pro) has significantly inhibitory activity against conidial germination of C. orbiculare and can reduce lesion occurrence [2]. Cyclo(-D-Leu-D-Pro) significantly inhibits the growth of A. parasiticus and reduced the production of aflatoxins[3]. Cyclo(-D-Leu-D-Pro) has been widely used as an internal reference to optimize the parameters of high-resolution gas chromatography-mass spectrometry (HRGC/MS) detection methods for quantifying cyclic dipeptides in lactic acid bacteria cultures[4].
References:
[1] Bailly C. Insights into the Bioactivities and Mechanism of Action of the Microbial Diketopiperazine Cyclic Dipeptide Cyclo (L-leucyl-L-prolyl)[J]. Marine Drugs, 2025, 23(10): 397.
[2] Kim J, Kim J C, Sang M K. Identification of isomeric cyclo (leu-pro) produced by Pseudomonas sesami BC42 and its differential antifungal activities against Colletotrichum orbiculare[J]. Frontiers in Microbiology, 2023, 14: 1230345.
[3] Yan P S, Song Y, Sakuno E, et al. Cyclo (L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus[J]. Applied and environmental microbiology, 2004, 70(12): 7466-7473.
[4] Axel C, Zannini E, Arendt E K, et al. Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay[J]. Analytical and bioanalytical chemistry, 2014, 406(9): 2433-2444.
Cyclo(-D-Leu-D-Pro)是一种来源于Pseudonocardia endophytica VUK-10的环状二肽，具有抗真菌活性[1]。Cyclo(-D-Leu-D-Pro)对C. orbiculare的分生孢子萌发具有显著抑制活性，并能减少病斑发生[2]。Cyclo(-D-Leu-D-Pro)显著抑制A. parasiticus的生长并减少黄曲霉毒素的产生[3]。Cyclo(-D-Leu-D-Pro)已被广泛用作内标，用于优化高分辨气相色谱-质谱(HRGC/MS)检测方法的参数，以定量乳酸菌培养物中的环状二肽[4]。
| Cas No. | 274680-11-4 | SDF | |
| 分子式 | C11H18N2O2 | 分子量 | 210.28 |
| 溶解度 | DMSO : 125 mg/mL (594.47 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7556 mL | 23.7778 mL | 47.5556 mL |
| 5 mM | 951.1 μL | 4.7556 mL | 9.5111 mL |
| 10 mM | 475.6 μL | 2.3778 mL | 4.7556 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet