Cyclo(-D-Leu-D-Pro) is a cyclic dipeptide from Pseudonocardia endophytica VUK-10, with antifungal activities [1]. Cyclo(-D-Leu-D-Pro) has significantly inhibitory activity against conidial germination of C. orbiculare and can reduce lesion occurrence [2]. Cyclo(-D-Leu-D-Pro) significantly inhibits the growth of A. parasiticus and reduced the production of aflatoxins[3]. Cyclo(-D-Leu-D-Pro) has been widely used as an internal reference to optimize the parameters of high-resolution gas chromatography-mass spectrometry (HRGC/MS) detection methods for quantifying cyclic dipeptides in lactic acid bacteria cultures[4].
References:
[1] Bailly C. Insights into the Bioactivities and Mechanism of Action of the Microbial Diketopiperazine Cyclic Dipeptide Cyclo (L-leucyl-L-prolyl)[J]. Marine Drugs, 2025, 23(10): 397.
[2] Kim J, Kim J C, Sang M K. Identification of isomeric cyclo (leu-pro) produced by Pseudomonas sesami BC42 and its differential antifungal activities against Colletotrichum orbiculare[J]. Frontiers in Microbiology, 2023, 14: 1230345.
[3] Yan P S, Song Y, Sakuno E, et al. Cyclo (L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus[J]. Applied and environmental microbiology, 2004, 70(12): 7466-7473.
[4] Axel C, Zannini E, Arendt E K, et al. Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay[J]. Analytical and bioanalytical chemistry, 2014, 406(9): 2433-2444.
Cyclo(-D-Leu-D-Pro)是一种来源于Pseudonocardia endophytica VUK-10的环状二肽，具有抗真菌活性[1]。Cyclo(-D-Leu-D-Pro)对C. orbiculare的分生孢子萌发具有显著抑制活性，并能减少病斑发生[2]。Cyclo(-D-Leu-D-Pro)显著抑制A. parasiticus的生长并减少黄曲霉毒素的产生[3]。Cyclo(-D-Leu-D-Pro)已被广泛用作内标，用于优化高分辨气相色谱-质谱(HRGC/MS)检测方法的参数，以定量乳酸菌培养物中的环状二肽[4]。