Anxiety Peptide, also known as Octadecaneuropeptide (ODN), is produced by trypsin digestion of diazepam binding inhibitor (DBI). Anxiety Peptide binds to benzodiazepine receptors and appears to increase anxiety[1]. The sequence of Anxiety Peptide is Gln-Ala-Thr-Val-Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys.
References:
[1] Marx J L. " Anxiety Peptide" Found in Brain: A peptide that occurs naturally in brain appears to act through the benzodiazepine receptor to bring about an increase in anxiety[J]. Science, 1985, 227(4689): 934-934.
Anxiety Peptide（焦虑肽），又称为Octadecaneuropeptide（十八神经肽；ODN），是通过地西泮结合抑制剂（DBI）的胰蛋白酶消化产生的。Anxiety Peptide与苯二氮卓受体结合，似乎会增加焦虑[1]。Anxiety Peptide的序列为Gln-Ala-Thr-Val-Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys。