Ac-Lys-NHMe is a small molecule model compound often used in peptide chemistry and biochemical research [1]. Ac-Lys-NHMe can be used as a reaction substrate to test the antibody cross-linking reaction caused by luminescent dyes with active groups[2]. Ac-Lys-NHMe can be used as a model molecule to study peptide chain folding, hydrogen bonds and secondary structures (such as β-angles and α-helices) [3].
References:
[1] Chen P, Sun J, Zhu C, et al. Cell‐active, reversible, and irreversible covalent inhibitors that selectively target the catalytic lysine of BCR‐ABL kinase[J]. Angewandte Chemie International Edition, 2022, 61(26): e202203878.
[2] Kolmakov K, Wurm C A, Meineke D N H, et al. Polar red‐emitting rhodamine dyes with reactive groups: synthesis, photophysical properties, and two‐color STED nanoscopy applications[J]. Chemistry–A European Journal, 2014, 20(1): 146-157.
[3] Ishii H, Okano T, Maeji N J, et al. The role of Lys side chains in the stabilization of β-turn structure[J]. Polymer journal, 1988, 20(1): 65-72.
Ac-Lys-NHMe是一种常用于肽化学与生物化学研究的小分子模型化合物[1]。Ac-Lys-NHMe可作为反应底物用于测试发光染料与活性基团引发的抗体交联反应[2]。Ac-Lys-NHMe可作为模型分子用于研究肽链折叠、氢键及二级结构（如β-转角与α-螺旋）的形成机制[3]。