Fursultiamine is a synthetic derivative of vitamin B1 .1 It reduces LPS-induced increases in IL-6, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) protein levels and decreases in mitochondrial respiration in ARPE-19 retinal pigment epithelial cells when used at concentrations of 100 and 20 ?M, respectively.2 Fursultiamine (50 mg/kg) also reduces the area and severity of laser-induced lesions in a mouse model of choroidal neovascularization (CNV). It increases thiamine levels in various rat tissues, including skeletal muscle and the heart, and prevents physical-fatigue loading decreases in skeletal muscle ATP levels induced by forced swimming with a weight load in rats when administered at a dose of 50 mg/kg.3 Fursultiamine (100 mg/kg) enhances the protective effects of glucosamine and chondroitin sulfate on cartilage lesion formation in a rabbit model of osteoarthritis.1
1.Kobayashi, T., Notoya, K., Nakamura, A., et al.Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritisInflamm. Res.54(6)249-255(2005) 2.Do, J.Y., Kim, J., Kim, M.-J., et al.Fursultiamine alleviates choroidal neovascularization by suppressing inflammation and metabolic reprogrammingInvest. Ophthalmol. Vis. Sci.61(12)24(2020) 3.Nozaki, S., Mizuma, H., Tanaka, M., et al.Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in ratsNutr. Res.29(12)867-872(2009)