Fumonisin B3-13C34 (FB3-13C34) is intended for use as an internal standard for the quantification of fumonisin B3 by GC- or LC-MS. FB3 is a mycotoxin that has been found in Fusarium.1 It is cytotoxic to primary rat hepatocytes when used at concentrations of 125, 250, and 500 µM.2 Dietary administration of FB3 (0.05%) for 14 or 21 days induces hepatocyte nodules, a marker of cancer initiation, in rats.2 FB3 has been detected in corn and corn-based foods and livestock feeds.3
1.Rheeder, J.P., Marasas, W.F.O., and Vismer, H.F.Production of fumonisin analogs by Fusarium speciesAppl. Environ. Microbiol.68(5)2101-2105(2002) 2.Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al.Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assaysFood Chem. Toxicol.31(6)407-414(1993) 3.Bullerman, L.B.Occurrence of Fusarium and fumonisins on food grains and in foodsFumonisins in food27-38(1996)