Fumonisin B2-13C34 (FB2-13C34) is intended for use as an internal standard for the quantification of FB2 by GC- or LC-MS. FB2 is a mycotoxin that has been found in F. moniliforme.1 It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).2 FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.3 FB2 has been detected in corn and corn-based foods and livestock feeds.4
1.Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al.Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliformeAppl. Environ. Microbiol.54(7)1806-1811(1988) 2.Shier, W.T., Abbas, H.K., and Mirocha, C.J.Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cellsMycopathologia116(2)97-104(1991) 3.Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al.Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assaysFood Chem. Toxicol.31(6)407-414(1993) 4.Bullerman, L.B.Occurrence of Fusarium and fumonisins on food grains and in foodsFumonisins in food27-38(1996)