Fmoc-Arg(Pbf)-OH is a protected amino acid derivative of arginine [1]. Fmoc-Arg(Pbf)-OH is a similar compound to Gly-Pro and Arg(Pbf)-OH, both of which are dipeptide structural units. The Pbf group of Fmoc-Arg(Pbf)-OH can be cleaved under moderately acidic conditions [2]. Fmoc-Arg(Pbf)-OH has been used in the solid-phase synthesis of peptides containing L-arginine [3].
References:
[1] Beatriz G, et al. Successful development of a method for the incorporation of Fmoc-Arg (Pbf)-OH in solid-phase peptide synthesis using N-butylpyrrolidinone (NBP) as solvent. Green Chemistry, 2020, 22(10): 3162-3169.
[2] Fields C G, Fields G B. Minimization of tryptophan alkylation following 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis[J]. Tetrahedron letters, 1993, 34(42): 6661-6664.
[3] Boullet H, Bentot F, Hequet A, et al. Small antimicrobial peptide with in vivo activity against sepsis[J]. Molecules, 2019, 24(9): 1702.
[4] Karlsen, E.A.; Stensen, W.; Juskewitz, E.; Svenson, J.; Berglin, M.; Svendsen, J.S.M. Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis. Antibiotics 2021, 10, 1516.
Fmoc-Arg(Pbf)-OH是一种受Fmoc保护的氨基酸衍生物，可用于制造含精氨酸的肽 [1]。Fmoc-Arg(Pbf)-OH是Gly-Pro和Arg(Pbf)-OH的类似物，后两者也是二肽结构单元。Fmoc-Arg（Pbf）-OH的Pbf基团可以在中等酸性条件下裂解 [2]。Fmoc-Arg(Pbf)-OH已用于含有 L-精氨酸的肽的固相合成 [3]。