Fluridone is a potent inhibitor of abscisic acid (ABA) biosynthesis and is used as a herbicide, particularly for the elimination of aquatic plants in reservoirs and irrigation channels[1].
Treatment of kiwifruit wound tissue with Fluridone inhibited the levels of transcription factors AchnMYB41, AchnMYB107 and AchnMYC2 and reduced primary alcohol formation[1]. Fluridone (50 and 100μM) induced the accumulation of phytoene and reduced β-carotene levels in T. aestivum seedlings grown in the dark[2].
Fluridone reduces the hatching success rate of medaka embryos in a dose-dependent manner, with the maximum effective concentration for hatching success being 2.3mg/L. Male and female medaka larvae were acutely exposed to Fluridone for 6 hours. Fluridone at concentrations of 4.2mg/L or higher caused the larvae to become lethargic and exhibit abnormal swimming behavior[3]. Fluridone is acutely toxic to invertebrates and fish, with median lethal concentrations (LC50) of 4.3 ± 3.7 and 10.4 ± 3.9mg/L, respectively[4].
References:
[1] Wei X, Mao L, Wei X, Xia M, Xu C. MYB41, MYB107, and MYC2 promote ABA-mediated primary fatty alcohol accumulation via activation of AchnFAR in wound suberization in kiwifruit. Hortic Res. 2020 Jun 1;7(1):86.
[2] Bartels P G, Watson C W. Inhibition of carotenoid synthesis by fluridone and norflurazon[J]. Weed Science, 1978, 26(2): 198-203.
[3] Jin J, Kurobe T, Hammock B G, et al. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)[J]. Science of the Total Environment, 2020, 700: 134495.
[4] Hamelink J L, Buckler D R, Mayer F L, et al. Toxicity of fluridone to aquatic invertebrates and fish[J]. Environmental Toxicology and Chemistry: An International Journal, 1986, 5(1): 87-94.
Fluridone是脱落酸（ABA）生物合成的有效抑制剂，可用作除草剂，特别是用于消除水库和灌溉渠道中的水生植物[1]。
使用Fluridone处理猕猴桃伤口组织可抑制转录因子AchnMYB41、AchnMYB107和AchnMYC2的水平，减少伯醇形成[1]。Fluridone（50和100μM）可诱导在黑暗中生长的T. aestivum 幼苗中八氢番茄红素的积累，减少β-胡萝卜素水平[2]。
Fluridone以剂量依赖性方式降低青鳉胚胎孵化成功率，孵化成功的半数最大有效浓度为2.3mg/L。雄性和雌性青鳉幼虫急性暴露于Fluridone 6小时，4.2mg/L或更高浓度的Fluridone使幼鱼变得嗜睡并表现出异常的游泳行为[3]。Fluridone对无脊椎动物和鱼类具有急性毒性，半数致死浓度 (LC50) 分别为4.3 ± 3.7和10.4±3.9mg/L[4]。