Flunixin-d3 is intended for use as an internal standard for the quantification of flunixin by GC- or LC-MS. Flunixin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 (IC50s = 3.24 and 0.55 µM, respectively).1 It inhibits carrageenan-induced prostaglandin E2 and thromboxane B2 production in sheep exudate and serum, respectively, when administered at a dose of 1.1 mg/kg.2 Flunixin (1.1 mg/L per kg) has anti-inflammatory, analgesic, and antipyretic activity in horses.3 Formulations containing flunixin have been used in the veterinary treatment of pain and fever in livestock.
1.Bryant, C.E., Farnfield, B.A., and Janicke, H.J.Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa BAm. J. Vet. Res.64(2)211-215(2003) 2.Cheng, Z., Nolan, A.M., and McKellar, Q.A.Measurement of cyclooxygenase inhibition in vivo: A study of two non-steroidal anti-inflammatory drugs in sheepInflammation22(4)353-366(1998) 3.Houdeshell, J.W., and Hennessey, P.W.A new nonsteroidal, anti-inflammatory analgesic for horsesJ. Equine Vet Sci.1(2)57-63(1977)