Flt-3L-Ig (hum/hum) (hFlt3L) is aFlt3activator. Flt-3L-Ig (hum/hum) enhances OKT3-induced inflammatory cytokine release from myeloid and dendritic cells in BRGSF-CBC mice, as well as the number and distribution of human immune cells, exhibiting cytokine release syndrome (CRS)[1].
References:
[1].Martin GH, et al. Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model. Front Immunol. 2024 Feb 7;15:1357716.
Flt-3L-Ig (hum/hum) (hFlt3L) 是一种Flt3激活剂。Flt-3L-Ig (hum/hum) 可增强 OKT3 诱导的 BRGSF-CBC 小鼠髓系细胞和树突状细胞炎性细胞因子的释放，以及人类免疫细胞的数量和分布，表现出细胞因子释放综合征 (CRS)。