Florbetapir is usually used as a reference standard to characterize florbetapir F-18 [1]. Florbetapir F-18 is a β-amyloid (Aβ) plaque-specific tracer for in vivo positron emission tomography (PET) imaging as a marker of Alzheimer’s disease (AD). Florbetapir F-18 has high Aβ binding affinity and can cross the blood-brain barrier [2-3].
References:
[1] Lister-James, John, et al. "Florbetapir f-18: a histopathologically validated Beta-amyloid positron emission tomography imaging agent." Seminars in nuclear medicine. Vol. 41. No. 4. WB Saunders, 2011.
[2] Wong, Dean, et al. "In vivo imaging of amyloid deposition in Alzheimer's disease using the novel radioligand [18F] AV-45." (2008): 214P-214P.
[3] Okamura, Nobuyuki, and Kazuhiko Yanai. "Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer’s disease." IDrugs 13.12 (2010): 890-899.
Florbetapir通常被用作检测Florbetapir F-18的参考标准品[1]。Florbetapir F-18 是一种针对β-淀粉样蛋白（Aβ）斑块的放射性示踪剂，用于体内正电子发射断层扫描（PET）成像，作为阿尔茨海默病（AD）的标志物。Florbetapir F-18 具有优良的 Aβ 结合亲和力，并且能够穿过血脑屏障[2-3]。