Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity.1,2 It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.3
1.Koepfli, J.B., Mead, J.F., and Brockman, J.A., Jr.An alkaloid with high antimalarial activity from Dichroa febrifugaJ. Am. Chem. Soc.69(7)1837(1947) 2.McLaughlin, N.P., Evans, P., and Pines, M.The chemistry and biology of febrifugine and halofuginoneBioorg. Med. Chem.22(7)1993-2004(2014) 3.Murata, K., Takano, F., Fushiya, S., et al.Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65Biochem. Pharmacol.58(10)1593-1601(1999)