FD-1080 is a fluorophore with excitation and emission light in the second near-infrared region II (NIR-II) (Ex=1064nm, Em=1080nm) that can be used for in vivo imaging[1]. FD-1080 has high quantum yield, deep tissue penetration depth, superior spatial resolution, outstanding signal-to-noise ratio, and dynamic imaging capabilities[1]. The quantum yield of FD-1080 in FBS solvent can be increased to 5.94%[2]. FD-1080 can not only achieve non-invasive and high-resolution bioimaging of deep tissue vascular and cerebral vessels in the hind limb, but also quantify respiratory rate based on dynamic imaging of craniocaudal respiratory movement in the liver of awake and anesthetized mice[3, 4].
References:
[1] Li B, Lu L, Zhao M, et al. An efficient 1064 nm NIR‐II excitation fluorescent molecular dye for deep‐tissue high‐resolution dynamic bioimaging[J]. Angewandte Chemie, 2018, 130(25): 7605-7609.
[2] Zhou H, Xiao Y, Hong X. New NIR-II dyes without a benzobisthiadiazole core[J]. Chinese Chemical Letters, 2018, 29(10): 1425-1428.
[3] He S, Cheng Z. Advancements of second near-infrared biological window fluorophores: Mechanism, synthesis, and application in vivo[J]. Fluorescent Imaging in Medicinal Chemistry, 2020: 81-123.
[4] Ding F, Fan Y, Sun Y, et al. Beyond 1000 nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep‐Tissue Molecular Imaging[J]. Advanced Healthcare Materials, 2019, 8(14): 1900260.
FD-1080是在第二近红外区II（NIR-II）区域中具有激发和发射光的荧光团（Ex=1064nm, Em=1080nm），可用于体内成像[1]。FD-1080具有高量子产率、深组织穿透深度、上级空间分辨率、突出的信噪比和动态成像能力[1]。FD-1080在FBS溶剂中的量子产率可提高至5.94%[2]。FD-1080不仅能够实现无创高分辨率的后肢深部组织血管和脑血管生物成像，而且能够基于清醒和麻醉小鼠肝脏呼吸头尾向运动的动态成像来量化呼吸频率[3, 4]。