GlpBio

Exendin-4 (5-39) amide (trifluoroacetate salt)

目录号: GC52411纯度: >95.00%同义词: Exenatide Amide
An antagonist of the GLP-1 receptor
Exendin-4 (5-39) amide (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥5,922.00现货
1
500 μg¥3,500.00现货
1
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产品描述 Description

Exendin-4 (5-39) amide is a 34-amino acid synthetic peptide corresponding to residues 5-39 of exendin-4 (48-86) amide and an antagonist of the glucagon-like peptide 1 (GLP-1) receptor (IC50 = 0.3 nM) that has roles in synaptic transmission.1 It decreases GLP-1-induced increases in intracellular cAMP levels in CHO/pancGLPR cells. Exendin-4 (5-39) amide (10 and 100 nM) increases extracellular glutamate reuptake in primary rat hippocampal astrocytes.2 In vivo, exendin-4 (5-39) amide increases excitatory amino acid transporter 2 (EAAT2) protein levels and decreases the field excitatory postsynaptic potential decay time in the rat dentate gyrus when administered intracerebroventricularly.

1.Montrose-Rafizadeh, C., Yang, H., Rodgers, B.D., et al.High potency antagonists of the pancreatic glucagon-like peptide-1 receptorJ. Biol. Chem.272(34)21201-21206(1997) 2.Kobayashi, K., Iwai, T., Sasaki-Hamada, S., et al.Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrusBrain Res.15051-10(2013)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
Exenatide Amide
SMILES
OC(C[C@H](NC([C@H](CO)NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@@]([C@H](O)C)([H])N[H])=O)CC1=CC=CC=C1)=O)=O)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(NCC(N4CCC[C@H]4C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@H](C(N5CCC[C@H]5C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)([H])[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O.O=C(O)C(F)(F)F
分子式
C169H262N44O54S ? XCF3COOH
分子量
3806.2 g/mol
溶解性
Water: soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol