Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein.
Euphornin (50-200 μg/mL, 48 h) markedly increases levels of cleaved caspase-3, caspase-8, caspase-9, and caspase-10[1].
References:
[1]. Li XQ, et al. Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest. Onco Targets Ther. 2018 Jul 27;11:4395-4405.