Etl acetoacetate-d3 is the deuterium labeled Etl acetoacetate. Etl acetoacetate (Etl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[1][2][3]. Etl acetoacetate is an inhibitor of bacterial biofilm[4].
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[5].
[1]. Rao M.Uppu, et al. Enantioselective catalytic asymmetric drogenation of etl acetoacetate in room temperature ionic liquids. Biochemical and Biopsical Research Communications. 1996 Dec; 229(3):764-769.
[2]. Leo F. Salter, et al. A dual‐frequency Belousov Zhabotinskii oscillating reaction with etl acetoacetate as organic substrate. substrate. International Journal of Chemical Kinetics. 1982. 14(8), 815-821.
[3]. Iqbal S, et al. 2-Oxo-1,2,3,4-tetradropyrimidines Etl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies. Med Chem. 2018;14(8):818-830.
[4]. Horne SM, et al. Acetoacetate and etl acetoacetate as novel inhibitors of bacterial biofilm. Lett Appl Microbiol. 2018 Apr;66(4):329-339.
[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.