Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2 Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women.
1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual cycleSteroids63(1)5-13(1998) 2.Adlercreutz, H., Brown, J., Collins, W., et al.The measurement of urinary steroid glucuronides as indices of the fertile period in womenJ. Steroid Biochem.17(6)695-702(1982)