β-Estradiol-d3 is a deuterated labeling compound of the endogenous estrogen 17β-Estradiol[1]. In liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS) analysis, β-Estradiol-d3 can serve as an ideal internal standard for determining the content of estradiol in biological samples[2]. In pharmacokinetic studies, β-Estradiol-d3 can serve as a tracer to track the absorption, distribution, metabolism and excretion of estradiol in vivo[3].
References:
[1] Cristina R T, Hanganu F, Dumitrescu E, et al. The impact of exogenic testosterone and nortestosterone-decanoate toxicological evaluation using a rat model[J]. PLoS One, 2014, 9(10): e109219.
[2] Van Hoeck E. Development of multi-residue and selective methods for the ultra-sensitive determination of endocrine disrupting chemicals in aqueous samples[D]. Ghent University, 2009.
[3] Russak E M, Bednarczyk E M. Impact of deuterium substitution on the pharmacokinetics of pharmaceuticals[J]. Annals of Pharmacotherapy, 2019, 53(2): 211-216.
β-Estradiol-d3是内源性雌激素17β-Estradiol的氘代标记化合物[1]。在液相色谱-质谱联用（LC-MS）或气相色谱-质谱联用（GC-MS）分析中，β-Estradiol-d3能够作为理想的内标，测定生物样本中雌二醇含量[2]。在药代动力学研究中，β-Estradiol-d3能够作为示踪剂，追踪雌二醇在体内的吸收、分布、代谢和排泄过程[3]。