Erianin is a benzoyl compound that has been found in D. chrysotoxum and has diverse biological activities.1,2,3 It inhibits the growth of H460 and H1299 lung cancer cells in a calcium/calmodulin-dependent manner, an effect that can be reversed by the ferroptosis inhibitor liproxstatin-1 or ferrostatin-1 .1 Erianin (100 mg/kg) reduces tumor volume in an H460 mouse xenograft model. It increases colon length and body weight, as well as decreases colonic inflammation and the number of colonic ulcers in a mouse model of ulcerative colitis induced by dextran sulfate .2 Erianin (10 mg/kg) decreases retinal microglia accumulation, NF-kB signaling, and TNF-α mRNA expression, as well as attenuates blood-brain barrier breakdown in a mouse model of diabetic retinopathy induced by streptozotocin .3
1.Chen, P., Wu, Q., Feng, J., et al.Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosisSignal Transduct. Target. Ther.5(1)51(2020) 2.Dou, D., Hu, W., Song, M., et al.Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3Chem. Biol. Interact.324109089(2020) 3.Zhang, T., Ouyang, H., Mei, X., et al.Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1/2-NF-κB signaling pathwayFASEB J.33(11)11776-11790(2019)