Epitetracycline (hydrochloride) is an epimer of the antibiotic tetracycline with low antibiotic activity [1]. Epitetracycline can be used as a reference substance to investigate the contribution of earthworms to the degradation performance of tetracycline in the soil[2]. Epitetracycline can be used as an internal reference to optimize high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the detection of tetracycline degradation status and the identification of related compounds[3].
References:
[1] Fritz J W, Zuo Y. Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography[J]. Food Chemistry, 2007, 105(3): 1297-1301.
[2] Lin Z, Zhen Z, Luo S, et al. Effects of two ecological earthworm species on tetracycline degradation performance, pathway and bacterial community structure in laterite soil[J]. Journal of hazardous materials, 2021, 412: 125212.
[3] Kühne M, Hamscher G, Körner U, et al. Formation of anhydrotetracycline during a high-temperature treatment of animal-derived feed contaminated with tetracycline[J]. Food chemistry, 2001, 75(4): 423-429.
Epitetracycline (hydrochloride)是抗生素四环素的差向异构体，抗生素活性较低[1]。Epitetracycline可用作参考物质，以研究蚯蚓对土壤中四环素降解性能的贡献[2]。Epitetracycline可用作内参，以优化高效液相色谱法和液相色谱-串联质谱法，用于检测四环素的降解状态并鉴定相关化合物[3]。