EphB1-IN-1

IC50: 3.0 nM (EphB1^G703C), 15 nM (EphB1^T697G), 220 nM (EphB1^WT)^[1]

EphB1-IN-1 (Compound 1) is a potent Inhibited EphB1^G703C. Abolished the autophosphorylation of EphB3^WT with little effect on that of EphB1^T697G. 100 nM of 3MB-PP1 abolished the autophosphorylation of EphB1^T697G but had little effect on that of EphB3^WT.

[1]. Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017 Jun 16;12(6):1499-1503.