EP2 receptor antagonist-3 is a selectiveEP2 receptorantagonist (IC50: 8 nM in hEP2 SPA assay, 50 nM in hEP2 cAMP assay). EP2 receptor antagonist-3 increases the macrophage-mediated clearance ofAmyloid-βplaques. EP2 receptor antagonist-3 can be used for the study of alzheimer’s diseases[1].
References:
[1].Fox BM, et al. A selective prostaglandin E2 receptor subtype 2 (EP2) antagonist increases the macrophage-mediated clearance of amyloid-beta plaques. J Med Chem. 2015 Jul 9;58(13):5256-73.
EP2 receptor antagonist-3 是一种具有选择性的 EP2 受体 (EP2 receptor) 拮抗剂 (hEP2 SPA实验测定IC50为 8 nM；hEP2 cAMP 实验测定IC50为 50 nM)。EP2 receptor antagonist-3 可增加巨噬细胞介导的Amyloid-β斑块清除。EP2 receptor antagonist-3 可用于阿尔茨海默病的研究。