ENPP1 inhibitor 43 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1; Ki = 41 nM).1 It inhibits tumor growth in an LLC1 murine lung cancer model when administered orally or intravenously at doses of 10 and 100 mg/kg, respectively.
1.Gangar, M., Goyal, S., Raykar, D., et al.Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapyBioorg. Chem.119105549(2022)