Emideltide, also known as delta sleep-inducing peptide (DSIP), is a synthetic nonapeptide sedative.1 In vivo, emideltide (30 nmol/kg, i.v.) increases EEG delta activity and induces orthodox slow-wave sleep in free-moving rabbits. It also increases non-rapid eye movement (NREM) and total sleep in free-moving rats.2
1.Monnier, M., Dudler, L., GÄchter, R., et al.Delta sleep-inducing peptide (DSIP): EEG and motor activity in rabbits following intravenous administrationNeurosci. Lett.6(1)9-13(1977) 2.Kafi, S., Monnier, M., and Gallard, J.M.The delta-sleep inducing peptide (DSIP) increases duration of sleep in ratsNeurosci. Lett.13(2)169-172(1979)
















