Eicosapentaenoic Acid-d5 ethyl ester

Eicosapentaenoic acid-d₅ etl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid etl ester by GC- or LC-MS. Eicosapentaenoic acid (EPA) etl ester is an esterified form of the ω-3 fatty acid EPA . Dietary administration of EPA etl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic β-oxidation enzymes.^1,2 It also reduces total hepatic triglyceride levels and increases the ω-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of ω-3 fatty acids in rats. EPA etl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.³ Formulations containing eicosapentaenoic acid etl ester have been used as adjuncts in the treatment of pertriglyceridemia.