Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 µM[1][2].
[1]. Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57(9):1213-9.
[2]. Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5.