Dodecanoic acid ingenol ester is an ingenane diterpene that has been found in E. kansui and has antiviral and antinematodal activities.1 It inhibits replication of HIV-1 in infected MT-4 cells (EC50 = 33.7 nM).2 Dodecanoic acid ingenol ester also has antinematodal activity against the plant pathogenic nematode B. xylophilus in a B. cinerea-based bioassay with a minimum effective dose (MED) of 2.5 ?g/cotton ball.1
1.Shi, J., Li, Z., Nitoda, T., et al.Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)Z. Naturforsch. C. J. Biosci.63(1-2)59-65(2008) 2.Liu, Q., Li, W., Huang, L., et al.Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansuiEur. J. Med. Chem.156618-627(2018)