Docosahexaenoyl serinol is a derivative of 2-docosahexaenoyl glycerol (2-DG). It inhibits the growth of A549 human lung adenocarcinoma cells (IC50 = 0.48 µM).[1] It also inhibits degranulation of RBL-2H3 mast cells (IC50 = 16 µM).[2] Oral administration of docosahexaenoyl serinol (20 mg/animal) suppresses the IgE-dependent passive cutaneous anaphylaxis (PCA) reaction by 17% in mice.
References:
[1].Tremblay, H., St-Georges, C., Legault, M.A., et al.One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative propertiesBioorg. Med. Chem. Lett.24(24)5635-5638(2014).
[2].Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019).