GLPBio

DMT7

目录号: GC92263纯度: >90.00%
DMT7 is an ionizable cationic lipid (pKa= 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and anticancer agents in vivo.
DMT7
规格价格库存数量操作
1mg¥1,047.00现货
1
5mg¥4,974.00现货
1
10mg¥9,425.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

DMT7 is an ionizable cationic lipid (pKa= 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and anticancer agents in vivo. LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and the STING agonist MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis. The same LNPs decrease the number of tumor-associated regulatory T cells (Tregs), increase the number of tumor-associated M1 macrophages, and increase intratumoral levels of Il-12, Il-2, Tnf-α, and Ifn-γ in a B16/F10 murine melanoma model.

产品文档 Product Documents

Purity:>90.00%Appearance:A solution in ethanol

化学性质Chemical Properties

化学名
1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea
SMILES
CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)NC(NCCN(C)C)=S
分子式
C42H79N3S
分子量
658.2 g/mol
溶解性
DMSO: Sparingly soluble: 1-10 mg/ml; Ethanol: Soluble: ≥10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol