DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].
3-hydroxy-3-methylglutaryl CoA (HMG-CoA) comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria[1].
[1]. MillÁn NÚÑez-CortÉs J, et al. FÁrmacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish.
[2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.