Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].
Disodium pyrophosphate (oral administration, 12.6 mg/kg) displays hematotoxic and immunotoxic effects with long-term exposure in rats[1].
| Animal Model: | Adult Sprague-Dawley rats[1] |
| Dosage: | 12.6 mg/kg |
| Administration: | Oral administration |
| Result: | Displayed significant leukopenic condition. Decreased in CD3 T-lymphocyte and CD20 Blymphocyte immunolabeling in rats. Downregulated of PPAR-α and PPAR-γ together with upregulation of TNF-α. |