Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active[1].
Dioxone is soluble in ethanol, ether, chloroform and propylene glycol. A 1 percent aqueous solution may be obtained at room temperature giving a pH of 4.3, and, with warming to 50℃, 2 percent aqueous solutions may be prepared[1].
Dioxone (0-30 mg/kg; i.v., i.p., oral, s.c.; once) induces convulsant action[1].
| Animal Model: | CF-1 Mice and CF-Wistar rats[1] |
| Dosage: | 0-30 mg/kg |
| Administration: | Intraperitoneal injection, once |
| Result: | In mice: The spontaneous activity was often reduced, always accompanied by perreactivity at 10 mg/kg, tremors, clonic convulsion and motor incoordination phenomena occured after the administration of 30 mg/kg. In rats: Tremors and some isolated clonus of the muscles of the limbs were observed with 10 mg/kg, clonic convukions occurred with doses above 15 mg/kg. |
[1]. G MAFFII, et al. A new analeptic: 5, 5-dietl-1, 3-oxazine-2,4-dione (Dioxone). J Pharm Pharmacol. 1961 Apr;13:244-53.