Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].
Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2].
Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1].
| Animal Model: | C57BL/6 mice with wound healing[1] |
| Dosage: | 0.25 mg |
| Administration: | Intraperitoneal injection; 0.25 mg once |
| Result: | Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing. |