Desmethylxanthohumol is a chalcone-type compound isolated from hops with anticancer activity[1]. Desmethylxanthohumol can inhibit the formation of biological membranes, disrupt the structure of biological membranes, and inhibit the growth of various bacteria[2]. Desmethylxanthohumol has been widely used in the inhibition of prostate cancer cell proliferation and in pharmacological comparative analysis[3].
In vitro, Desmethylxanthohumol treatment for 48 hours significantly inhibited the viability of human umbilical vein endothelial cells (HUVECs), with an IC50 value of 18.92µM[4].
References:
[1] Vogel S, Ohmayer S, Brunner G, et al. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity[J]. Bioorganic & medicinal chemistry, 2008, 16(8): 4286-4293.
[2] Bocquet L, Sahpaz S, Bonneau N, et al. Phenolic compounds from Humulus lupulus as natural antimicrobial products: new weapons in the fight against methicillin resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei strains[J]. Molecules, 2019, 24(6): 1024.
[3] Delmulle L, Bellahcene A, Dhooge W, et al. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines[J]. Phytomedicine, 2006, 13(9-10): 732-734.
[4] Teng Y, Li X, Yang K, et al. Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers[J]. European Journal of Medicinal Chemistry, 2017, 125: 335-345.
Desmethylxanthohumol是一种从啤酒花中分离出的查耳酮类化合物，具有抗癌活性[1]。Desmethylxanthohumol能够抑制生物膜的形成，破坏生物膜结构，并抑制多种细菌的生长[2]。Desmethylxanthohumol已被广泛用于抑制前列腺癌细胞增殖以及进行药理学比较分析[3]。
在体外，Desmethylxanthohumol处理48小时显著抑制了人脐静脉内皮细胞（HUVECs）的活力，IC50值为18.92µM[4]。