Desmethylxanthohumol是一种从啤酒花中分离出的查耳酮类化合物，具有抗癌活性。
Cas No.:115063-39-3
Sample solution is provided at 25 µL, 10mM.
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Desmethylxanthohumol is a chalcone-type compound isolated from hops with anticancer activity[1]. Desmethylxanthohumol can inhibit the formation of biological membranes, disrupt the structure of biological membranes, and inhibit the growth of various bacteria[2]. Desmethylxanthohumol has been widely used in the inhibition of prostate cancer cell proliferation and in pharmacological comparative analysis[3].
In vitro, Desmethylxanthohumol treatment for 48 hours significantly inhibited the viability of human umbilical vein endothelial cells (HUVECs), with an IC50 value of 18.92µM[4].
References:
[1] Vogel S, Ohmayer S, Brunner G, et al. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity[J]. Bioorganic & medicinal chemistry, 2008, 16(8): 4286-4293.
[2] Bocquet L, Sahpaz S, Bonneau N, et al. Phenolic compounds from Humulus lupulus as natural antimicrobial products: new weapons in the fight against methicillin resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei strains[J]. Molecules, 2019, 24(6): 1024.
[3] Delmulle L, Bellahcene A, Dhooge W, et al. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines[J]. Phytomedicine, 2006, 13(9-10): 732-734.
[4] Teng Y, Li X, Yang K, et al. Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers[J]. European Journal of Medicinal Chemistry, 2017, 125: 335-345.
Desmethylxanthohumol是一种从啤酒花中分离出的查耳酮类化合物，具有抗癌活性[1]。Desmethylxanthohumol能够抑制生物膜的形成，破坏生物膜结构，并抑制多种细菌的生长[2]。Desmethylxanthohumol已被广泛用于抑制前列腺癌细胞增殖以及进行药理学比较分析[3]。
在体外，Desmethylxanthohumol处理48小时显著抑制了人脐静脉内皮细胞（HUVECs）的活力，IC50值为18.92µM[4]。
| Cell experiment [1]: | |
Cell lines | HUVECs |
Preparation Method | HUVECs were cultured in Dulbecco minimal Eagle's medium (DMEM) supplemented with 10% fetal bovine serum at 37°C in a 5% CO2 incubator. HUVECs cells (100μl) were cultured in 96-well plates at a density of 5×103 cells per well for 24h. different concentrations of Desmethylxanthohumol (0.1, 1, 10, 50, and 100µM) were added to each well to culture for additional 48h. Then, the cell viability was analyzed. |
Reaction Conditions | 0.1, 1, 10, 50, and 100µM; 48h |
Applications | Desmethylxanthohumol treatment significantly reduced the cell death of HUVECs in a dose-dependent manner. |
References: | |
| Cas No. | 115063-39-3 | SDF | |
| 别名 | 去甲黄腐醇 | ||
| 分子式 | C20H20O5 | 分子量 | 340.37 |
| 溶解度 | 储存条件 | Store at 2-8°C,protect from light | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.938 mL | 14.6899 mL | 29.3798 mL |
| 5 mM | 587.6 μL | 2.938 mL | 5.876 mL |
| 10 mM | 293.8 μL | 1.469 mL | 2.938 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
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