Demetleneberberine chloride is a natural mitochondria-targeted antioxidant. Demetleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting AMPK activator for researching non-alcoholic fatty liver disease (NAFLD)[1][2][3].
[1]. Zhang P, et al. Demetleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47.
[2]. Chen YY, et al. Demetleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196.
[3]. Qiang X, et al. Demetleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biops Res Commun. 2016 Apr 15;472(4):603-9.