Deltamethrin-d5 is intended for use as an internal standard for the quantification of deltamethrin by GC- or LC-MS. Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1 It activates Nav1.8 channels and induces a tail current delay in Xenopus oocytes expressing the rat channel when used at a concentration of 10 ?M. Deltamethrin induces mortality in A. sinensis (LC50 = 4.522 ppm) and T. urticae (LC50 = 0.06 g/L).2,3 It decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats when administered at a dose of 5 mg/kg.4 Formulations containing deltamethrin have been used as domestic and agricultural insecticides.
1.Choi, J.S., and Soderlund, D.M.Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytesToxicol. Appl. Pharmacol.211(3)233-244(2006) 2.Chang, K.-S., Yoo, D.-H., Shin, E.-H., et al.Susceptibility and resistance of field populations of Anopheles sinensis (Diptera: Culicidae) collected from Paju to 13 insecticidesOsong Public Health Res. Perspect.4(2)76-80(2013) 3.Penman, D.R., Chapman, R.B., and Bowie, M.H.Direct toxicity and repellent activity of pyrethroids against Tetranychus urticae (Acari: Tetranychidae)J. Econ. Entomol.79(5)1183-1187(1986) 4.Abdallah, F.B., Slima, A.B., Dammak, I., et al.Comparative effects of dimethoate and deltamethrin on reproductive system in male miceAndrologia42(3)182-186(2010)