Dehydrocholic acid is a synthetic bile acid and a derivative of cholic acid .1 It increases bile flow by 2.7-fold and decreases biliary levels of phospholipids, cholesterol, and bilirubin in conscious dogs when administered at a dose of 50 mg/kg.2 Dehydrocholic acid (1 ?mol/min/0.1 kg) increases bile flow by 253% and decreases the secretion rate of phospholipids and cholesterol by 64 and 94%, respectively, in rats when infused intravenously at a dose of 2 ?mol/min/0.1 kg.3
1.Soloway, R.D., Hofmann, A.F., Thomas, P.J., et al.Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in manJ. Clin. Invest.52(3)715-724(1973) 2.Yanaura, S., and Ishikawa, S.Choleretic properties of ursodeoxycholic acid and chenodeoxycholic acid in dogsJpn. J. Pharmacol.28(3)383-389(1978) 3.Yousef, I.M., Mignault, D., Weber, A.M., et al.Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in ratsDigestion45(1)40-51(1990)