dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells[1].
dCeMM1 (0-100 µM; 3 days) 抑制细胞生长，WT 和 UBE2Mmut KBM7 细胞的 EC50 分别为 3、8 µM[1 ].
dCeMM1 (10 µM; 12, 16 h) 降低 WT KBM7 细胞中 RBM39 的表达水平[1]。
Western Blot Analysis[1]
| Cell Line: | WT and UBE2Mmut KBM7 cells |
| Concentration: | 10 µM |
| Incubation Time: | 12, 16 h |
| Result: | Decreased the expression of RBM39 levels in WT KBM7 cells. |
[1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207.