DBCO-amine features a highly strained cyclooctyne structure and is commonly used in free-copper click chemistry reactions[1]. The amino terminus of DBCO-amine can react with functional groups such as carboxyl groups to form amide bonds, which are utilized for conjugating biological molecules including proteins, antibodies, and nucleic acids[2].
References:
[1] Ackermann U, Jäger L, Rigopoulos A, et al. 18F-labeling and initial in vivo evaluation of a Hitomi peptide for imaging tissue transglutaminase 2. Nucl Med Biol. 2023 Jan-Feb;116-117:108308.
[2] Fuku R, Liu Y, Giuliana P, et al. Efficient Dual Surface Modification of Cellulose Nanocrystals with Hydrophobic Moieties and Functional Polymers via a Grafting-to Approach. Biomacromolecules. 2025 Sep 8;26(9):6233-6243.
DBCO-amine具有高应变的环辛炔结构，常用于无铜点击化学反应[1]。DBCO-amine的氨基端可与羧基等基团反应形成酰胺键，用于连接蛋白质、抗体、核酸等生物分子[2]。