GlpBio

(D)-PPA 1 (trifluoroacetate salt)

目录号: GC52442纯度: >98.00%同义词: DPPA-1, NYSKPTDRQYHF
An inhibitor of the PD-1-PD-L1 protein-protein interaction
(D)-PPA 1 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥3,080.00现货
1
5 mg¥7,294.00现货
1
10 mg¥10,528.00现货
1
500 μg¥1,624.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

(D)-PPA 1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).1 It binds to the extracellular domain of PD-L1 (Kd = 0.51 µM for the recombinant human protein). (D)-PPA 1 (2 mg/kg) decreases tumor volume and improves survival in a CT26 murine colorectal cancer model.

1.Chang, H.-N., Liu, B.-Y., Qi, Y.-K., et al.Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapyAngew. Chem. Int. Ed. Engl.54(40)11760-11764(2015)

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

同义词
DPPA-1, NYSKPTDRQYHF
SMILES
OC(C=C1)=CC=C1C[C@@H](NC([C@H](N)CC(N)=O)=O)C(N[C@H](CO)C(N[C@H](CCCCN)C(N2[C@H](CCC2)C(N[C@H]([C@@H](O)C)C(N[C@H](CC(O)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式
C70H98N20O21 ? XCF3COOH
分子量
1555.7 g/mol
溶解性
DMF: 10 mg/mL,DMSO: 10 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 5 mg/mL
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol