[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes andPD-L1expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes.
References:
[1]. Yih Ho,et al. Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells.Food Chem Toxicol.2019 Nov;133:110808.
















