D-(+)-Fucose is a monosaccharide that is an enantiomer of L-(-)-fucose and analog of L-arabinose.1 It inhibits induction of the L-arabinose operon and has been used to increase the yield and activity of recombinant proteins.2,3
1.Flowers, H.M.Chemistry and biochemistry of D- and L-fucoseAdvances in Carbohydrate Chemistry and Biochemistry39279-345(1981) 2.Beverin, S., Sheppard, D.E., and Park, S.S.D-Fucose as a gratuitous inducer of the L-arabinose operon in strains of Escherichia coli B-r mutant in gene araCJ. Bacteriol.107(1)79-86(1971) 3.Jung, K.-H., Park, Y.-S., Yeon, J.-H., et al.Improving the yield of soluble 6xHis-tagged interferon-α via the addition of repressor of the araBAD promoter system in Escherichia coliBiotechnol. Lett.30(9)1577-1582(2008)