GlpBio

CYM 2503

目录号: GC49767纯度: >95.00%同义词: (9H-芴-9-基)甲基((S)-1(((S)-6-(叔丁氧基羰基)氨基-1-((4-甲基-2-氧代-1,2-二氢喹啉-7-基)氨基)-1-氧代己-2-基)氨基)-3-环己基-1-氧代丙-2-基)氨基甲酸叔丁酯
A GAL2 receptor positive allosteric modulator
CYM 2503
Cas No.: 1308833-36-4
规格价格库存数量操作
1mg¥419.00现货
1
5mg¥1,033.00现货
1
10mg¥1,654.00现货
1
25mg¥3,285.00现货
1
50mg¥4,932.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

CYM 2503 is a positive allosteric modulator (PAM) of the galanin-2 (GAL2) receptor.1 It enhances the production of inositol monophosphate (IP1) induced by galanin in HEK293 cells expressing the GAL2 receptor (EC50 = 0.69 µM). CYM 2503 (60 mg/kg) increases the latency to first electrographic and behavioral seizures and reduces mortality in a lithium-pilocarpine (Li-pilocarpine) rat model of status epilepticus.

1.Lu, X., Roberts, E., Xia, F., et al.GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal modelsProc. Natl. Acad. Sci. USA107(34)15229-15234(2010)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
1308833-36-4
同义词
(9H-芴-9-基)甲基((S)-1(((S)-6-(叔丁氧基羰基)氨基-1-((4-甲基-2-氧代-1,2-二氢喹啉-7-基)氨基)-1-氧代己-2-基)氨基)-3-环己基-1-氧代丙-2-基)氨基甲酸叔丁酯
SMILES
CC(C1=CC=C(C=C1N2)NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC3CCCCC3)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=CC2=O
分子式
C45H55N5O7
分子量
778 g/mol
溶解性
DMSO : 100 mg/mL (128.54 mM; Need ultrasonic)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol