Cyfluthrin-d6

Cyfluthrin-d₆ is intended for use as an internal standard for the quantification of cyfluthrin by GC- or LC-MS. Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Na_v).^1,2 It slowly activates rat recombinant Na_v1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents in channels expressed in X. laevis oocytes.¹ It also decreases the mean burst rate in rat primary neurons (IC₅₀ = 0.99 μM, respectively).² Cyfluthrin is toxic to various insects, including A. melinus, G. ashmeadi, E. eremicus, and E. formosa (LC₅₀s = 7, 67, 96, and 63 ng/ml, respectively) and the A. sinensis mosquito (LC₅₀ = 0.446 ppm).^3,4 It is also toxic to A. mellifera honeybees (LD₅₀ = 0.22 ppm), affecting locomotor activity and wing fanning behavior with an increase in the mean bout duration of time spent upside down, indicating disruption of the righting reflex, and a decrease in wing fanning behavior when administered at a dose of 10 ng/bee.⁵ Formulations containing cyfluthrin have been used for the control of insects in agriculture and for non-commercial purposes.