Cycleanine is an alkaloid that has been found in T. subcordata and has anticancer and antimalarial activities.1,2 It selectively inhibits the growth of OVCAR-8, A2780, IGROV-1, and OVCAR-4 ovarian cancer cells (IC50s = 10, 7.6, 14, and 7.2 ?M, respectively) over non-cancerous ovarian surface epithelial cells (IC50 = 35 ?M).1 It also halts the cell cycle at the subG1 phase and induces apoptosis in OVCAR-8 cells. Cycleanine (25 and 50 mg/kg) reduces parasitemia and increases survival in a mouse model of infection with a chloroquine-resistant strain of P. berghei.2
1.Uche, F.I., Drijfhout, F.P., McCullagh, J., et al.Cytotoxicity effects and apoptosis induction by bisbenzylisoquinoline alkaloids from Triclisia subcordataPhytother. Res.30(9)1533-1539(2016) 2.Uche, F.I., Guo, X., Okokon, J., et al.In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of semisynthetic analoguesAntimicrob. Agents Chemother.65(2)e01995-01920(2021)