Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.1 It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
1.Lahm, G.P., Selby, T.P., Stevenson, T.M., et al.Pyrazolylpyridine activators of the insect ryanodine receptorBioactive heterocyclic compound classes: Agrochemicals251-263(2012)