Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer[1][2].
Curcumin-β-D-glucuronide (90 mg/kg; i.p. thrice a week for 3 weeks) exhibit potent anti-tumor effects on KRASm/TP53w HCT116 xenograft model[1].
[1]. Ozawa-Umeta H, et, al. Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer Sci. 2020 May;111(5):1785-1793.
[2]. Ozawa H, et, al. Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biol Pharm Bull. 2017;40(9):1515-1524.