GlpBio

CTX-1211 (trifluoroacetate salt)

目录号: GC92092纯度: >95.00%同义词: Acetyl-Arg-cyclo(Cys-D-Ala-Arg-D-Phe-Arg-Trp-Cys)-NH<sub>2</sub>
CTX-1211 (trifluoroacetate salt)是黑皮质素受体的肽激动剂。
CTX-1211 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥406.00现货
1
5 mg¥1,932.00现货
1
10 mg¥3,458.00现货
1
25 mg¥7,112.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

CTX-1211 is a peptide agonist of melanocortin receptors.1 It increases intracellular cAMP levels in cells expressing melanocortin receptor 1 (MC1R), MC3R, or MC4R (EC50s = 6.2, 3.9, and 2.7, nM, respectively). CTX-1211 (1 mg/kg) sensitizes male and female mice to reductions in food intake and body weight induced by liraglutide but with a lower effect on food intake in female mice.2

References:
[1]. Sharma, S.Peptide Compositions(2014).
[2]. Dahir, N.S., Gui, Y., Wu, Y., et al.Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in miceJ. Clin. Invest.134(14)e178250(2024).

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

同义词
Acetyl-Arg-cyclo(Cys-D-Ala-Arg-D-Phe-Arg-Trp-Cys)-NH<sub>2</sub>
化学名
N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-arginyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2→8)-disulfide, trifluoroacetate salt
SMILES
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H]1C)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)CC3=CNC4=CC=CC=C34.OC(C(F)(F)F)=O
分子式
C49H73N19O9S2 ? XCF3COOH
分子量
1136.4 g/mol
溶解性
Ethanol: Sparingly soluble: 1-10 mg/ml,PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
保存条件
-20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol