IC50: 21 μM (CSNK1A1 kinase)[1]
CSNK1-IN-1 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC50 values of 21 μM. CSNK1-IN-1 can be used for the research of proliferative disorders[1].
CSNK1-IN-1 对 CSNK1A1, CSNK1D 和 CSNK1A1 (高 ATP) 具有抑制活性，IC50 值分别为 21 μM, 29.7 μM 和 1.5 nM[1]。< br / >CSNK1-IN-1 对野生型 EGFR 激酶表现出低抑制作用，其 IC50 值为 >20 nM[1]。
[1]. Volker Schulze, et al. 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetradro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. Patent. WO2020161257 A1.