CSF1R Protein, Human

目录号: GC27027纯度: >98%

CSF1R蛋白普遍存在于单核吞噬细胞，特别是巨噬细胞和单核细胞中，并参与多种生物过程。它响应 IL34 和 CSF1 诱导促炎趋化因子的释放，有助于先天免疫和炎症。CSF1R 蛋白, Human (HEK293, His-Fc) 是重组的 CSF1R 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。

规格	价格	库存	数量
2ug	¥315.00	现货	1
10ug	¥531.00	现货	1
50ug	¥1,485.00	现货	1
100ug	¥2,520.00	现货	1

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Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

CSF1R 蛋白尤其存在于巨噬细胞和单核细胞等单核吞噬细胞中，参与多种生物过程。它响应 IL34 和 CSF1 促进促炎趋化因子的释放，有助于先天免疫和炎症过程。此外，CSF1R 对于调节破骨细胞增殖和分化、骨吸收、正常骨骼和牙齿发育至关重要。它也是男性和女性正常生育能力以及怀孕期间乳腺中乳管和腺泡结构发育所必需的。

产品文档 Product Documents

Purity:>98%

COA SDS Data Sheet

Product Data

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Source

HEK293

Physical Appearance

Lyophilized powder.

Synonyms

CSF1R 蛋白; HEK293, His-Fc; Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS

Amino Acid Sequence

IPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDE

Apparent Molecular Weight

115-125 kDa Da

Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Biological Activity

1. Measured by its ability to inhibit the M-CSF-induced proliferation of M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 1.402 ng/mL in the presence of 1 ng/mL of Recombinant Human M-CSF. corresponding to a specific activity is 7.133×105 units/mg. 2. Loaded CSF1R Protein, Human (HEK293, His-Fc) on HIS1K biosensor, can bind Axatilimab with an affinity constant of 1.467E-11 M as determined in BLI assay.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.